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Natalie Castellanos Ryan

Professeur·e d’université | UdeM - Université de Montréal

Natalie Castellanos-Ryan est chercheure au CHU Sainte-Justine de Montréal et professeure agrégée à l'École de psychoéducation, Université de Montréal. 

La recherche de Dr Castellanos Ryan porte sur l'étude du développement humain de la naissance au jeune âge adulte, y compris le développement comportemental, cognitif et socio-émotionnel. En collaboration avec autres, ses travaux suivent des cohortes longitudinales de grossesse et de naissance d'enfants et de leurs familles jusqu'à l'âge adulte, en examinant les facteurs biologiques et sociaux en jeu au cours du développement. Plus spécifiquement, l’expertise de Dr Castellanos-Ryan inclut : 1) le développement de la toxicomanie et les troubles de santé mentale, 2) des facteurs de risque/protection partagés entre les troubles de santé mentale, en particulier les troubles extériorisés, 3) leurs conséquences, et 4) leur prévention. Intérêts plus spécifiques comprennent aussi comment les déficits d'autorégulation (l'impulsivité), ainsi que le développement pubertaire et cognitif, prédisent, en interaction avec de facteurs environnementaux, les problèmes de toxicomanie et la comorbidité psychopathologique chez les jeunes.

Mes liens avec l'Acfas

Responsable
90e Congrès de l'Acfas : Les facteurs individuels et familiaux dans le développement de la santé mentale des jeunes : résultats des cohortes longitudinales québécoises
Conférencière
90e Congrès de l'Acfas : Prédicteurs individuels et familiaux de la santé mentale des enfants et des jeunes : la contribution des cohortes longitudinales québécoises
90e Congrès de l'Acfas : Présentations rapides (speed talks) : anxiété, dépression et comportements suicidaires
90e Congrès de l'Acfas : Prédicteurs individuels et familiaux de la santé mentale des enfants et des jeunes : la contribution des cohortes longitudinales québécoises
Coauteure
82e congrès de l'Acfas : Susceptibilité différentielle à l’environnement : interaction entre le tempérament et les pratiques parentales à 6 ans dans la prédiction de l’utilisation d’alcool à 15 ans
90e Congrès de l'Acfas : Description de trois cohortes longitudinales clés du Québec : cohortes 1 et 2 de l’ELDEQ-1 et l’étude 3D

Principal secteur de recherche ou d'activité

Sciences de la santé

Mes intérêts de recherche

Épidémiologie et biostatistique Neurosciences Psychiatrie Psychologie Psychoéducation

Mes publications

Articles in peer-reviewed journals since 2017 

  1. Castellanos-Ryan, N. (2023) The Value of Lumping and Splitting in the Study of Addiction and Psychopathology. Biological Psychiatry, 93 (6), 485-486.
  2. **Pocuca, N., Geoffroy, M.C., Paquin, S., Archambault, K., Séguin, J. R., Parent, S., Boivin, M., Tremblay, R. E., Côté, S. M., Castellanos-Ryan N. (2023) A thorough investigation of the bifactor model of psychopathology in a representative birth cohort: Testing internal and predictive validity to inform models of comorbidity. Journal of Psychopathology and Clinical Science, 132 (2), 123-134.
  3. Pocuca, N., Chadi, N., Vergunst, F., Parent, S., Côté, S.M., Boivin, M., Tremblay, R.E., Séguin, F.R. & Castellanos-Ryan, N. (2023) Prospective Polysubstance use Profiles Among Adolescents with Early-onset Cannabis Use, and their Association with Cannabis Outcomes in Emerging Adulthood. Int J Ment Health Addiction, https://doi.org/10.1007/s11469-022-01005-7.
  4. *Chaput-Langlois, S., Parent, S., †Castellanos-Ryan, N., Vitaro, F., & Séguin, J. R. (2022). Do I Behave like my Friends or do my Friends Behave like me? Substance Use in Adolescence and the Moderating Role of Attachment. Journal of Applied Developmental Psychology. https://doi.org/10.1016/j.appdev.2022.101457
  5. *Larose, M., *Pinsonneault, M., Castellanos-Ryan, N., Tremblay, R., Séguin, J. & Parent, S. (in press). Contribution de différents comportements extériorisés à la qualité du soutien affectif maternel au préscolaire. Revue de Psychoéducation.
  6. **Pocuca, N., Séguin, J. R., Parent, S., Boivin, M., Tremblay, R. E., Côté, S. M., Castellanos-Ryan N. (2022) The moderating role of sex and self-, teacher-, and father-reported ADHD-hyperactivity-impulsivity symptoms on the association between early adolescent internalizing symptoms and substance use, Addictive Behaviours, 135, 107437.
  7. **Morin, É., **Murray, J., **Rioux, C., & Castellanos-Ryan, N. (2022) Favoriser le recrutement des parents dans les programmes d’habiletés parentales pour les comportements extériorisés : Revue systématique. Revue de Psychoéducation, 51 (2), 283-310.
  8. *Pinsonneault, M., Parent, S., Castellanos-Ryan, N., Tremblay, R.E., Séguin, J.R. (in press) Transactional associations between vocabulary and disruptive behaviors during the transition to formal schooling. Development and Psychopathology, doi: 10.1017/S0954579422000268. Online ahead of print.
  9. **Leblond, M., Parent, S., Castellanos-Ryan, N., Lupien, S., Fraser, W.D., Séguin, J.R. (2022). Transition from Preschool to School: Children’s Pattern of Change in Morning Cortisol Concentrations. Psychoneuroendocrinology. https://doi.org/10.1016/j.psyneuen.2022.105724
  10. **Pocuca, N., **London-Nadeau, K., Geoffroy, M.-C., Chadi, N., Séguin, J. R., Parent, S., Boivin, M., Tremblay, R. E., Côté, S. M., & Castellanos-Ryan, N. (2022). Changes in emerging adults’ alcohol and cannabis use from before to during the COVID-19 pandemic: Evidence from a prospective birth cohort. Psychology of Addictive Behaviors. Advance online publication. https://doi.org/10.1037/adb0000826
  11. *Dumont, É., Castellanos-Ryan, N., Parent, S., Jacques, S., Séguin, J. R., & Zelazo, P. D. (2022). Transactional longitudinal relations between accuracy and reaction time on a measure of cognitive flexibility at 5, 6, and 7 years of age. Developmental Science, 00, e13254. https://doi.org/10.1111/desc.13254
  12. *Iqbal, M., Cox, S.M.L., Jaworska, N., Tippler, M., Castellanos-Ryan, N., Parent, S., Dagher, A., Vitaro, F., Brendgen, M.R., Boivin, M., Pihl, R.O., Côté, S.M., Tremblay, R.E., Séguin, J.R., Leyton, M. (2022). A three-factor model of common early onset psychiatric disorders: temperament, adversity, and dopamine. Neuropsychopharmacol. 47, 752–758 (2022). https://doi.org/10.1038/s41386-021-01187-z
  13. *Watkins-Martin, K., Orri, M., Pennestri, M.-H., Castellanos-Ryan, N., Larose, S., Gouin, J.-P., Ouellet-Morin, I., Chadi, N., Philippe, F., Boivin, M., Tremblay, R.E., Côté, S., Geoffroy. M.-C. (2021). Depression and Anxiety Symptoms in Young Adults Before and During the COVID-19 Pandemic: Evidence from a Canadian Population-Based Cohort. Annals of General Psychiatry, 20 (1), 1-12, doi: https://doi.org/10.1101/2021.04.23.21255994
  14. Chadi, N., Castellanos-Ryan, N., & Geoffroy, M.-C. (2021). COVID-19 and the impacts on youth mental health: emerging evidence from longitudinal studies. Canadian Journal of Public Health.
  15. Paquin V, Muckle G, Bolanis, Courtemanche, D.Y., Castellanos-Ryan, N., Boivin, M., Tremblay, R., Côté, S., Geoffroy, M.C. (2021). Longitudinal Trajectories of Food Insecurity in Childhood and Their Associations With Mental Health and Functioning in Adolescence. JAMA Netw Open, 4 (12):e2140085. doi:10.1001/jamanetworkopen.2021.40085
  16. Newton, N. C., Stapinski, L., Slade, T., Sunderland, M., Barrett, E., Champion, K., Chapman, K., Smout, A., Lawler, S., Mather, M., Debenham, J., Castellanos-Ryan, N., Conrod, P., & Teesson, M. (2021). The effectiveness of school-based alcohol use prevention from adolescence (13 years) to early adulthood (20 years): 7-year outcomes from a cluster randomised controlled trial of universal and selective interventions. Journal of the American Academy of Child and Adolescent Psyquiatry, https://doi.org/10.1016/j.jaac.2021.10.023
  17. **Rioux, C., *Huet, A.S., †Castellanos-Ryan, N., **Le Blanc, M., Hamaoui, S., Parent, S., Geoffroy, M.-C., Renaud, R., Séguin, J.R. (2021) Substance use and suicidal risk in youth: A meta-analysis with a focus on the direction of the association. Plos One, https://doi.org/10.1371/journal.pone.0255799.
  18. Vergunst, F., Chadi, N., Orri, M., Brousseau-Paradis, C., Castellanos-Ryan, N., Séguin, J.R., Vitaro, F., Nagin, D., Tremblay, R.E., & Côté, S.M. (2021) Trajectories of adolescent poly-substance use and their long-term social and economic outcomes for males from low-income backgrounds. Eur Child Adolesc Psychiatry (2021). https://doi.org/10.1007/s00787-021-01810-w
  19. Castellanos-Ryan, N., **Morin, É., **London-Nadeau, K., **Rioux, C., *Leblond, M. (2021). Academic, socioeconomic and interpersonal consequences of cannabis use: A narrative review. Drugs: Education, Prevention & Policy, https://doi.org/10.1080/09687637.2021.1906846.
  20. **Rioux. C., Parent, S., Castellanos-Ryan, N., Archambault, I., Boivin, M., Herba, C.M., Lupien, S.J., Marc, I., Muckle, G., Fraser, W.D. & Séguin, J.R. (2021). The 3D-Transition Study: Objectives, Methods, and Implementation of an Innovative Planned Missing Data Design. American Journal of Epidemiology, kwab141, https://doi.org/10.1093/aje/kwab141. 
  21. **London-Nadeau, K., **Rioux, C., Parent, S., Vitaro, F., Côté, S., Boivin, M., Tremblay, R., Séguin, J. & †Castellanos-Ryan, N. (2021) Longitudinal associations of cannabis, depression and anxiety in heterosexual and LGB adolescents. Journal of Abnormal Psychology, 130(4), 333–345. https://doi.org/10.1037/abn0000542 . 
  22. Laporte, C., Pereira, B., Orri, M., Chadi, N., Castellanos-Ryan, N., Brousse, G., Séguin, J., Xu, Q., Vitaro, F., Tremblay, R., Boivin, M., & Côté, S. (2021). Associations of childhood sociability and responsibility with cannabis use trajectories during adolescence: results from a prospective population-based birth cohort study. European Child & Adolescent Psychiatry, https://doi.org/10.1007/s00787-021-01730-9 . 
  23. Cox, S. M. L., Castellanos-Ryan, N., Parent, S., Benkelfat, C., Vitaro, F., Pihl, R.O., Boivin, M., Tremblay, R.E., Leyton, M., Séguin, J.R. (2021) Externalizing Risk Pathways for Substance Use Problems: A Birth Cohort Study. Canadian Journal of Psychiatry, https://doi.org/10.1177/0706743720982429.
  24. Bolanis, D., Orri, M., Castellanos-Ryan, N., Renaud, J., Montreuil, T., Boivin, M., Tremblay, R., Turecki, G., Côté, S., Séguin, J. & Vitaro, F. (2020) Cannabis use, depression and suicidal ideation in Canadian adolescents: comorbidity and direction of associations. Journal of Affective Disorders, 274, 1076-1083, https://doi.org/10.1016/j.jad.2020.05.136.
  25. Orri, M., Séguin, J. R., Castellanos-Ryan, N., Tremblay, R. E., Côté, S. M., Turecki, G., & Geoffroy, M.-C. (2020). A genetically informed study on the association of cannabis, alcohol, and tobacco smoking with suicide attempt. Molecular Psychiatry, https://doi.org/10.1038/s41380-020-0785-6.
  26. Cox, S., Tippler, M. , Jaworska, N., Smart, K., Castellanos-Ryan, N., Durand, F., Allard, D., Benkelfat, C., Parent, S., Dagher, A., Vitaro,F. Boivin, M., Pihl, R., Côté, S., Tremblay, R., Séguin, J. & Leyton, M. (2020) mGlu5 Receptor Availability in Youth at Risk for Addictions: Effects of Vulnerability Traits and Cannabis Use. Neuropsychopharmacology, 45 (11), 1817-1825, https://doi.org/10.1038/s41386-020-0708-x.
  27. Revill, A. S., Patton, K. A., Connor, J. P., Sheffield. J., Wood, A. P., Castellanos-Ryan, N., & Gullo, M. J. (2020). From impulse to action? Cognitive mechanisms of impulsivity-related risk for externalizing behavior. Journal of Abnormal Child Psychology, 48 (8), 1023-1034, https://doi.org/10.1007/s10802-020-00642-7.
  28. Jaworska, N., Cox, S., Tippler, M., Castellanos-Ryan, N., Benkelfat, C., Parent, S., Dagher, A., Vitaro,F. Boivin, M., Pihl, R., Côté, S., Tremblay, R., Séguin, J. & Leyton, M. (2020). Extra-striatal D2/3 Receptor Availability in Youth at Risk for Addiction. Neuropsychpharmacology, 45, 1498–1505. https://doi.org/10.1038/s41386-020-0662-7
  29. *Paquin, C., Paquin, S., Castellanos-Ryan, N., Séguin, J., Côté, S., Vitaro, F., Boivin, M., Herba, C. (2020). Maternal depressive symptoms, child behavior problems and their transactional relations: Probing the role of formal childcare. Development and Psychopathology, 32, 3, 831-844, https://doi.org/10.1017/S0954579419000956.
  30. **Rioux, C., **Murray, J., †Castellanos-Ryan, N., Séguin, J.R., Tremblay, R.E., Parent, S. (2020) Moderation of parenting by inhibitory control in the prediction of the common and unique variance of hyperactivity-impulsivity and inattention. Development and Psychopathology, 32 (3), 909-921, https://doi.org/10.1017/S0954579419000774.
  31. Edalati, H., Afzali, M. H., Castellanos-Ryan, N., Conrod, P.J. (2019) The Effect of Contextual Risk Factors on the Effectiveness of Brief Personality-targeted Interventions for Adolescence Alcohol Misuse: A Cluster Randomised Trial. Alcoholism: Clinical and Experimental Research, 43(5):997-1006. https://doi.org/10.1111/acer.14016 .
  32. Farooqi, N.A., Scotti, M., Yu, A., Lew, J., Monnier, P., Botteron, K.N., Campbell, B.C., Booij, L., Herba C.M., Séguin, J.R., Castellanos-Ryan, N., McCracken, J.T., Nguyen, T.V. (2018) Sex‐specific Contribution of DHEA‐Cortisol Ratio to Prefrontal‐Hippocampal Structural Development, Cognitive Abilities and Personality Traits. Journal of Neuroendocrinology, e12682. https://doi.org/10.1111/jne.12682 .
  33. *Dupont, C., Castellanos-Ryan, N., Séguin, J., Muckle, G., Simard, M.-N., Shapiro, G.D., Herba, C., Fraser, W., & Lippé, S. (2018) The Predictive Value of Head Circumference Growth during the First Year of Life on Early Child Traits. Scientific Reports (Nature), 8 (1), 9828. https://doi.org/10.1038/s41598-018-28165-8.
  34. **Rioux, C., †Castellanos-Ryan, N., Parent, S., Vitaro, F., & Séguin, J. (2019) The interactive effects of parental knowledge with impulsivity and sensation seeking in adolescent substance use. Child Psychiatry & Human Development, 50, 95-107. https://doi.org/10.1007/s10578-018-0825-5.
  35. Newton, N.C., Stapinski, L., Slade, T., Champion, K.E., Barrett, E.L., Chapman, C., Smout, A., Lawler, S., Mather, M., Castellanos-Ryan, N., Conrod, P.J. & Teesson, M. (2018). Pathways to prevention: Protocol for the CAP (Climate and Preventure) study to evaluate the long-term effectiveness of school-based universal, selective and combined alcohol misuse prevention into early adulthood. BMC Public Health, 18 (1), 643. https://doi.org/10.1186/s12889-018-5554-y
  36. Baker, T.E., Castellanos-Ryan, N.,  Schumann, G., Cattrell, A., Flor, H., Nees, F., Banaschewski, T., Bokde, A., Whelan, B., Bueche, C., Bromberg, U., Papadopoulos Orfanos, D., Gallinat, J., Garavan, H., Heinz, A., Walter, H., Brühl, R., Gowland, P., Paus, T., Poustka, L., Martinot, J.-L., Lemaitre, H., Artiges, E., Paillère Martinot, M.-L., Smolka, M.N., Conrod, P.J. and the Imagen Consortium (2019). Modulation of orbitofrontal-striatal reward activity by dopaminergic functional polymorphisms contributes to a predisposition to alcohol misuse in early adolescence. Psychological Medicine, 49, 801-810. https://doi.org/10.1017/S0033291718001459.
  37. MacLeod, A., Castellanos Ryan, N., Parent, S., Jacques, S., Séguin, J. (2019). Modelling vocabulary development among multilingual children prior to and following school entry. International Journal of Bilingual Education and Bilingualism, 22 (4), 473-492, DOI: http://dx.doi.org/10.1080/13670050.2016.1269718 .
  38. **Rioux, C., †Castellanos-Ryan, N., Parent, S., Vitaro, F., Tremblay, R. E. & Séguin, J. (2018) Age of cannabis use onset and adult drug abuse symptoms: a prospective study of common risk factors and indirect effects. Canadian Journal of Psychiatry, 63 (7), 457-464. http://journals.sagepub.com/doi/full/10.1177/0706743718760289
  39. *Perrier-Ménard, E., Castellanos Ryan, N., O'Leary-Barrett, M., Girard, Al., Conrod, P. (2017) The impact of youth internalising and externalising symptom severity on the effectiveness of brief personality-targeted interventions for substance misuse:  A cluster randomised trial. Addictive behaviors, 75, 138-144. https://doi.org/10.1016/j.addbeh.2017.07.015
  40. Brière, F.N., Pascal, S., Dupéré, V., Castellanos-Ryan, N., Allard, F., Yale-Soulière, G. & Janosz, M. (2017) Depression and Anxious symptoms and the risk of secondary school dropout. British Journal of Psychiatry, 211, 163-168. DOI: https://doi.org/10.1192/bjp.bp.117.201418
  41. Fernández-Calderón, F., Díaz Batanero, C., Lozano, O. M., Rojas Tejada. A.J., Castellanos-Ryan, N. (2017). Psychometric properties of the substance use risk profile scale: the Spanish version for the European context. Adicciones, 0, 909. https://doi.org/10.20882/adicciones.909.
  42. Castellanos-Ryan, N., Parent, S., Vitaro, F., Tremblay, R.E., Séguin, J. (2017) Adolescent Cannabis Use, change in neurocognitive function at 20 years of age, and high-school graduation: a prospective longitudinal/observational study. Development and Psychopathology, 29 (4), 1253-1266. DOI: https://doi.org/10.1017/S0954579416001280.
  43. **Marschall-Lévesque, S., †Castellanos-Ryan, N., Parent, S., Renaud, J., Vitaro, F., Boivin, M., Tremblay, R.E. & Séguin, J.R. (2017) Peer Victimization, Suicidal Ideation and Alcohol use in Adolescence: a Longitudinal Study Supporting the Self-Medication Model. Journal of Adolescent Health, 60 (4), 380-387. http://dx.doi.org/10.1016/j.jadohealth.2016.09.019

Chapter of a book or collective work OR book or collective work edition since 2017 

  1. **Murray, J., *Pinsonneault, M., Parent, S. & Castellanos-Ryan, N. (accepted). La prévention des comportements extériorisés par des interventions auprès des parents à la petite enfance. In Turgeon, L. & Parent, S. (Ed.) Intervention cognitivo-comportementale auprès des enfants et des adolescents: Troubles de comportement (2e édition). Montréal : Presses de l’Université du Québec.
  2. Castellanos-Ryan, N. & Conrod, P.J. (2020). Cognitive risk factors for alcohol and substance addictions. In Verdejo-Garcia, A. (Ed.) Cognition and Addiction: A Researcher’s Guide from Mechanisms Towards Interventions. Amsterdam: Elsevier. https://www.elsevier.com/books/cognition-and-addiction/garcia/978-0-12-815298-0
  3. Castellanos-Ryan, N., **Rioux, C., & **London-Nadeau, K. (2019). Conséquences psychosociales de l’usage de cannabis. In Brochu, S., Fallu, J.-S., & Pelletier, M. (Eds.) Cannabis. Montréal: Les Presses de l’Université de Montréal. https://www.pum.umontreal.ca/catalogue/cannabis