Jonathan Perreault
Mes principaux intérêts de recherche sont sur les ARN non-codants chez les bactéries (tels que ribozymes et riboswitchs) de même que les applications des acides nucléiques dans le domaine des biosenseurs et de la détection d'analytes en général.
Mes liens avec l'Acfas
Conférencierje suis chercheur à l'INRS au Québec (en biochimie, microbiologie, biologie moléculaire) et fait partie de la francophonie. J'ai aussi plusieurs étudiants qui participent régulièrement au congrès.
Principal secteur de recherche ou d'activité
Mes intérêts de recherche
Biologie moléculaire Biochimie Microbiologie Biotechnologies et biométrie Virologie et bactériologieMa formation
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2001 - 2007Université de SherbrookeDoctorat | BiochimieCanada
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2007 - 2010Yale UniversityPostdoctorat | Microbiologie et biochimieÉtats-Unis
Mes publications
Toehold-mediated strand displacement to measure released product from self-cleaving ribozymes (2022) JB Kapadia, N Kharma, AN Davis, N Kamel, J Perreault. RNA 28 (2), 263-273
Small RNAs beyond Model Organisms: Have We Only Scratched the Surface? (2022) E Boutet, S Djerroud, J Perreault. International journal of molecular sciences 23 (8), 4448
Analysis of non-coding RNAs in Methylorubrum extorquens reveals a novel small RNA specific to Methylobacteriaceae (2022) E Boutet, S Djerroud, K Smail, MJ Lorain, M Wu, M Lamarche, R Imane, ... bioRxiv
Identification of 11 candidate structured noncoding RNA motifs in humans by comparative genomics (2021) L Hou, J Xie, Y Wu, J Wang, A Duan, Y Ao, X Liu, X Yu, H Yan, J Perreault, ... BMC genomics 22 (1), 1-14
Digital Microfluidics Chips for the Execution and Real-Time Monitoring of Multiple Ribozymatic Cleavage Reactions (2021) AN Davis, K Samlali, JB Kapadia, J Perreault, SCC Shih, N Kharma. ACS omega 6 (35), 22514-22524
Electrochemical characterization of graphene-type materials obtained by electrochemical exfoliation of graphite (2021) Y Lei, BD Ossonon, J Chen, J Perreault, AC Tavares. Journal of Electroanalytical Chemistry 887, 115084
A survey of cis regulatory non-coding RNA involved in bacterial virulence (2021) MR Naghdi, S Djerroud, K Smail, J Perreault. bioRxiv
High-sensitivity small-molecule detection of microcystin-LR cyano-toxin using a terahertz-aptamer biosensor (2021) A Mohamed, R Walsh, M Cherif, HA Hafez, X Ropagnol, F Vidal, ... Analyst 146 (24), 7583-7592
Fluoride-Controlled Riboswitch-Based Dampening of Gene Expression for Cloning Potent Promoters. (2021) V Korniakova, A Devinck, MC Groleau, E Déziel, J Perreault. Frontiers in genetics 12, 591543-591543
Real-time isothermal DNA amplification monitoring in picoliter volumes using an optical fiber sensor (2021) M Janik, SV Hamidi, M Koba, J Perreault, R Walsh, WJ Bock, M Śmietana. Lab on a Chip 21 (2), 397-404
Computer-Aided Design of Active Pseudoknotted Hammerhead Ribozymes (2021) S Najeh, K Zandi, S Djerroud, N Kharma, J Perreault. Ribozymes, 91-111
Novel strategies to optimize the amplification of single-stranded DNA (2021) A Nehdi, N Samman, V Aguilar-Sánchez, A Farah, E Yurdusev, ... Frontiers in Bioengineering and Biotechnology 8, 401
Single Mutation in Hammerhead Ribozyme Favors Cleavage Activity with Manganese over Magnesium (2020) MR Naghdi, E Boutet, C Mucha, J Ouellet, J Perreault. Non-coding RNA 6 (1), 14
An experimentally evolved variant of RsmA confirms its central role in the control of Pseudomonas aeruginosa social motility (2020) S Robitaille, YL de los Santos, MC Groleau, F Jean-Pierre, N Doucet, ... bioRxiv
Bioinspired carbohydrate-decorated long-period fiber grating for label-free bacteria detection (2019) A Celebanska, Y Chiniforooshan, M Janik, P Mikulic, B Sellamuthu, ... IEEE Sensors Journal 19 (24), 11965-11971
Gold coated dual-resonance long-period fiber gratings (DR-LPFG) based aptasensor for cyanobacterial toxin detection (2019) SM Tripathi, K Dandapat, WJ Bock, P Mikulic, J Perreault, B Sellamuthu. Sensing and Bio-Sensing Research 25, 100289
Simple rolling circle amplification colorimetric assay based on pH for target DNA detection (2019) SV Hamidi, J Perreault. Talanta 201, 419-425.
Label-free cocaine aptasensor based on a long-period fiber grating (2019) A Celebanska, Y Chiniforooshan, M Janik, P Mikulic, B Sellamuthu, ... Optics letters 44 (10), 2482-2485
RNA-Based Therapy Utilizing Oculopharyngeal Muscular Dystrophy Transcript Knockdown and Replacement (2019) A Abu-Baker, N Kharma, J Perreault, A Grant, M Shekarabi, C Maios, ... Molecular Therapy-Nucleic Acids 15, 12-25
Room-Temperature and Selective Triggering of Supramolecular DNA Assembly/Disassembly by Nonionizing Radiation (2019) GMA Greschner AA, Ropagnol X, Kort M, Zuberi N, Perreault J, Razzari L, Ozaki T. J Am Chem Soc. 141 ((8)), 3456-3469
Genetically engineered c1-utilizing microorganisms and processes for their production and use (2018) MG Lamarche, J Perreault, C Miguez, M Arbour, YJ Choi US Patent App. 15/566,579
Peptide modification results in the formation of a dimer with a 60-fold enhanced antimicrobial activity (2017) A Thamri, M Létourneau, A Djoboulian, D Chatenet, E Déziel, ... PloS one 12 (3), e0173783
Search for 5′-leader regulatory RNA structures based on gene annotation aided by the RiboGap database (2017) MR Naghdi, K Smail, JX Wang, F Wade, RR Breaker, J Perreault. Methods 117, 3-13
Transcriptional pausing at the translation start site operates as a critical checkpoint for riboswitch regulation (2017) A Chauvier, F Picard-Jean, JC Berger-Dancause, L Bastet, MR Naghdi, ... Nature communications 8 (1), 1-12
Automated design of hammerhead ribozymes and validation by targeting the PABPN1 gene transcript (2016) N Kharma, L Varin, A Abu-Baker, J Ouellet, S Najeh, MR Ehdaeivand, ... Nucleic acids research 44 (4), e39-e39
Complex autoregulation of the post-transcriptional regulator RsmA in Pseudomonas aeruginosa (2015) F Jean-Pierre, J Perreault, E Deziel. Microbiology 161 (9), 1889-1896
Aerobic sludge granulation in a reverse flow baffled reactor (RFBR) operated in continuous-flow mode for wastewater treatment (2015) J Li, A Cai, L Ding, B Sellamuthu, J Perreault. Separation and Purification Technology 149, 437-444
Finding instances of riboswitches and ribozymes by homology search of structured RNA with Infernal (2015) A El Korbi, J Ouellet, MR Naghdi, J Perreault. Therapeutic Applications of Ribozymes and Riboswitches, 113-126
Expression Strategy of Aedes albopictus Densovirus (2014) HT Pham, FX Jousset, J Perreault, H Shike, J Szelei, M Bergoin, P Tijssen. Journal of virology 87 (17), 9928-9932
Identification of quorum sensing‐controlled genes in Burkholderia ambifaria (2013) A Chapalain, L Vial, N Laprade, V Dekimpe, J Perreault, E Déziel. MicrobiologyOpen
The ubiquitous hammerhead ribozyme (2012) C Hammann, A Luptak, J Perreault, M De La Peña. RNA 18 (5), 871-885
Identification of hammerhead ribozymes in all domains of life reveals novel structural variations (2011) J Perreault, Z Weinberg, A Roth, O Popescu, P Chartrand, G Ferbeyre, ... PLoS computational biology 7 (5), e1002031
Exceptional structured noncoding RNAs revealed by bacterial metagenome analysis (2009) Z Weinberg, J Perreault, MM Meyer, RR Breaker. Nature 462 (7273), 656-659
A novel structural rearrangement of hepatitis delta virus antigenomic ribozyme (2007) A Nehdi, J Perreault, JD Beaudoin, JP Perreault. Nucleic acids research 35 (20), 6820-6831
Ro-associated Y RNAs in metazoans: evolution and diversification (2007) J Perreault, JP Perreault, G Boire. Molecular biology and evolution 24 (8), 1678-1689
RTAnalyzer: a web application for finding new retrotransposons and detecting L1 retrotransposition signatures (2007) JF Lucier, J Perreault, JF Noel, G Boire, JP Perreault. Nucleic acids research 35 (suppl_2), W269-W274
Characterization of the MCT-1 pseudogene: Identification and implication of its location in a highly amplified region of chromosome 20 (2006) S Nandi, B Shi, J Perreault, RB Gartenhaus. Biochimica et Biophysica Acta (BBA)-Gene Structure and Expression 1759
Retropseudogenes derived from the human Ro/SS-A autoantigen-associated hY RNAs (2005) J Perreault, JF Noel, F Briere, B Cousineau, JF Lucier, JP Perreault, ... Nucleic acids research 33 (6), 2032-2041
Formation of the P1. 1 pseudoknot is critical for both the cleavage activity and substrate specificity of an antigenomic trans‐acting hepatitis delta ribozyme (2003) P Deschênes, J Ouellet, J Perreault, JP Perreault. Nucleic acids research 31 (8), 2087-2096
SubViral RNA: a database of the smallest known auto-replicable RNA species (2003) M Pelchat, L Rocheleau, J Perreault, JP Perreault. Nucleic acids research 31 (1), 444-445
Mes affiliations
- Professeur agrégé INRS - Centre Armand-Frappier Santé Biotechnologie ARN Québec ARN Canada Riboclub Centre for Applied Synthetic Biology (CASB) CRIPA