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Image de profil de Alexandre Poirier

Alexandre Poirier

Principal secteur de recherche ou d'activité

Sciences de la santé

Mes intérêts de recherche

Immunologie Biochimie Biologie cellulaire Biologie moléculaire Génie biomédical et génie biochimique

Ma formation

  • 2019 - 2024
    Université McGill
    Doctorat | Immunologie et immunothérapie
    Canada

Mes contributions « Science et société »

  • Communication scientifique sur YouTube

Mes publications

  1. Poirier, A; Picard, C; Labonté, A; Miron, J; Auld, D; the PREVENT-AD research group; The Alzheimer's Disease Neuroimaging Initiative; Zetterberg, H; Blennow, K; Tremblay, ML; Poirier, J. (2023). PTPRS is a novel marker for early tau pathology and synaptic integrity in Alzheimer’s disease. Molecular Psychiatry (In revision).
  2. Feng, C; Peltier, L; Chouleur, T; Perez-Quintero, LA;  Poirier, A; Bikfalvi, A; Vidal, S; Laneuville, P, Tremblay, ML. (2023). Enhancement of human natural killer cell anti-tumor cytolysis function via dual inhibition of PTPN1 and PTPN2. Journal of Clinical Investigation (Submitted).
  3. Poirier, A; Ormonde, JVS; Aubry, A; Abidin, BM; Feng, C; Cordova, ZM; Hincapie, AM; Perez-Quintero, L-A; Wang, C; Madrenas, J; Gingras, AC; Tremblay, M.L. (2023). Induction of SHP-1 degradation by TAOK3 ensures responsiveness of T cell receptor signaling. Science Signaling (Accepted).
  4. Poirier, A; Wu, C; Hincapie, AM; Abidin, BM; Cordova, ZM; Tremblay, M.L. (2023). TAOK3 limits age-associated inflammation by negatively modulating macrophage differentiation and their production of TNFα. Immunity and Ageing.
  5. Perez-Quintero, Poirier, A; L-A; Cordoba, ZM; Carli, C; Feng, C; Kamyabiazar, S; Aubry, A; Pacis, A; Zolotarov, Y; Pike , KA; Delisle, J-S; Tremblay, M.L. (2023). Combined inhibition of homologous immunotherapeutic targets PTPN1 and PTPN2 is synergistic in enhancing CD8 T cell effector functions. bioRxiv.
  6. Poirier, A; Tremblay, M.L. (2022). Pharmacological potentiation of monocyte-derived dendritic cell cancer immunotherapy. Cancer Immunology, Immunotherapy.
  7. Picard, C*; Poirier, A*; Bélanger, S; Labonté, A; Auld, D; Poirier, J. (2019). Proprotein convertase subtilisin/kexin type 9 (PCSK9) in Alzheimer’s disease: A genetic and proteomic multi-cohort study. PLOS ONE. *co-first authors.